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Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

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Related Experiment Video

Updated: Jul 7, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

The connection between C-reactive protein and atherosclerosis.

Sanjay K Singh1, Madathilparambil V Suresh, Bhavya Voleti

  • 1Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.

Annals of Medicine
|February 23, 2008
PubMed
Summary

C-reactive protein (CRP) levels correlate with cardiovascular disease. While research shows mixed results on whether CRP is atherogenic or atheroprotective, its role in human atherosclerosis remains unclear.

Related Experiment Videos

Last Updated: Jul 7, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Biochemistry

Background:

  • High-sensitivity C-reactive protein (hs-CRP) serum concentrations correlate with cardiovascular disease risk.
  • C-reactive protein (CRP) interacts with modified and native low-density lipoprotein (LDL), and is found at atherosclerotic lesions.
  • CRP's cellular effects are under re-evaluation with purified CRP preparations, free of contaminants.

Purpose of the Study:

  • To investigate the multifaceted role of C-reactive protein (CRP) in the development of atherosclerosis.
  • To explore the proatherogenic and atheroprotective functions of CRP in experimental models.

Main Methods:

  • Correlation analysis of hs-CRP serum levels with cardiovascular disease incidence.
  • In vitro studies on mammalian cell responses to CRP treatment.
  • In vivo studies using experimental rats and a murine model (Apob(100/100) Ldlr(-/-)) of atherosclerosis, assessing CRP's effects on infarct size and atheroprotection.

Main Results:

  • CRP concentration is linked to cardiovascular disease occurrence.
  • Experimental models show conflicting results: CRP increased infarct size in rats but was atheroprotective in a murine model.
  • CRP's interaction with LDL and complement activation pathways influences its effects.

Conclusions:

  • CRP exhibits complex and context-dependent roles in atherosclerosis.
  • Further research is needed to definitively determine if CRP protects humans against atherosclerosis.