Related Experiment Video
Updated: Jul 7, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Expression of COX-2 and prognostic outcome in uveal melanoma
Lorna M Cryan1, Luminita Paraoan, Paul Hiscott
1School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, and Department of Ophthalmology, Mater Misericordiae Hospital, Dublin, Ireland.
Purpose:
The expression of cyclooxygenase-2 (COX-2) and its prognostic value in uveal melanoma was examined.
Methods:
Paraffin-embedded sections from 32 clinicopathologically well-characterized cases of primary uveal melanoma were immunohistochemically stained for COX-2. COX-2 expression was evaluated in terms of both the intensity and the extent of staining for each tumor. A COX-2 score encompassing both intensity and extent was also calculated for each specimen.
Results:
29 specimens (90.6%) contained moderate or intense positive immunoreactivity for COX-2. A statistically significant association (p<0.05) between COX-2 expression (intensity and score) and metastatic death was established.
Conclusion:
Upregulation of COX-2 expression appears to be associated with poor prognosis in uveal melanoma.
Related Concept Videos
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
