Related Experiment Video
Updated: Jul 7, 2026
Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis
Published on: November 8, 2024
Placental growth factor (PlGF) is a surrogate marker in preeclamptic hypertension
Patrícia Gonçalves Teixeira1, Antônio Carlos Vieira Cabral, Silvia Passos Andrade
1Fetal Medicine Center, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Objective:
To evaluate plasma levels of angiogenic factors and their association with preeclampsia.
Methods:
Twenty-three women with preeclampsia and nine normotensive pregnant women from the Maternity of Hospital das Clínicas of Belo Horizonte/MG-Brazil were assessed by National High Blood Pressure Education Program Working Group Creteria (NHBPEPWG). The plasma levels of vascular endothelial growth factor (VEGF) and Placental growth factor (PlGF) were determined by ELISA assay.
Results:
Plasma concentration of PlGF was 12-fold lower in preeclampsia versus non preeclampsia pregnancies. An inverse correlation was observed between PlGF plasma levels and mean arterial pressure (MAP); a decrease in 1pg/mL of PlGF resulted in 6.18 mm Hg increase in MAP.
Conclusion:
These results indicate that PlGF is related to MAP in pregnant women.
