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Related Experiment Video

Updated: Jul 7, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Published on: August 8, 2022

Cirrhotic cardiomyopathy.

Saleh A Alqahtani¹, Tamer R Fouad, Samuel S Lee

¹Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Seminars in Liver Disease

|February 23, 2008

Summary

This summary is machine-generated.

Cirrhotic cardiomyopathy, a heart condition in liver cirrhosis patients, impairs cardiac response to stress. Liver transplantation may improve this condition over time.

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Area of Science:

Cardiology
Hepatology
Internal Medicine

Background:

Liver cirrhosis presents with cardiovascular abnormalities, including cirrhotic cardiomyopathy.
This condition is characterized by a suboptimal ventricular response to stress despite increased baseline cardiac output.

Purpose of the Study:

To summarize the understanding of cirrhotic cardiomyopathy, its pathogenesis, clinical implications, and treatment.

Main Methods:

Review of existing literature on cirrhotic cardiomyopathy.
Analysis of the multifactorial pathogenesis, including beta-adrenergic signaling, cardiomyocyte dysfunction, and cardiodepressant substances.
Evaluation of clinical manifestations and treatment strategies.

Main Results:

Cirrhotic cardiomyopathy involves impaired beta-adrenergic signal transduction, cardiomyocyte membrane dysfunction, and elevated cardiodepressant substances.
While often subclinical, it can manifest as overt heart failure under stress (e.g., liver transplantation, TIPS).
It may contribute to hepatorenal syndrome development.

Conclusions:

Cirrhotic cardiomyopathy is a complex syndrome with significant clinical implications in liver disease.
Current treatment is primarily supportive, with orthotopic liver transplantation showing potential for long-term improvement.