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Updated: Jul 7, 2026
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Neonatal morbidity and mortality in HELLP syndrome]
Gerardo Flores Nava1, Victor Hugo Jurado Hernández, Aurora Martínez Mondragón
1Unidad de Cuidados Intensivos Neonatales, Hospital de Ginecoobstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social. gerflores50@hotmail.com
Introduction:
HELLP syndrome (HS) is a pregnancy complication with hemolysis, hepatic failure and thrombocytopenia. This syndrome increase maternal, fetus and neonatal morbidity and mortality.
Objective:
To compare clinical features, morbidity, mortality and hematological outcome in a group with and without HS. The variables were analyzed with t'Students, chi square, and Fisher test, p significative value was < 0.05.
Results:
We analyzed 60 patients in both groups, and we found differences in (HS group vs no HS); Cesarean section 96 vs 68%, gestational age 33 +/- 3 vs 35 +/- 3, birth weight 1819 +/- 604 vs 2263 +/- 797 grams, length 42 +/- 5 vs 45 +/- 4 cm, preterm infants 88.3% vs 55%, intraventricular hemorrhage 26.6 vs 8.3%, hypocalcaemia 26.6 vs 48.3%. In the first day of life, hematic cytology with Hto 52 +/- 7 vs 49 +/- 8, platelets 153,804 +/- 947 vs 192,822 +/- 61,070 and uncongugated bilirubin 5.2 +/- 3.7 vs 3.8 +/- 1.9 were observed. At 2nd day leucocytes 8030 +/- 4094 vs 18020 +/- 12606 and granulocytes 4734 +/- 30307 vs 9324 +/- 9776 were found. No differences was found in, maternal age, intrauterine growth restriction, gender, respiratory distress syndrome, asphyxia, sepsis and hepatic enzymes, morbidity 83.3 vs 86.6% (p = 0.79), and mortality 5 vs 1.6% (p = 0.61).
Conclusions:
HS is an important cause of premature delivery. The neonatal morbidity is typical of preterm infants, intraventricular hemorrhage was more frequent. Mortality was not different.
