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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
[Morbidity in newborns of term associated with tract of birth]
Aída Delgado Becerra1, María del Rosario Ortiz Almeralla, Luis A Fernández Carrocera
1Departamento de alojamiento conjunto, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, México DF.
Insights
Newborns born via vaginal delivery face higher injury risks than those from abdominal deliveries. However, respiratory issues were similar, though C-sections after labor showed fewer breathing problems than planned C-sections.
Area of Science:
- Perinatal medicine
- Neonatal outcomes
- Obstetrics
Context:
- Birth injuries and respiratory diseases pose significant risks in the perinatal period.
- Incidence rates vary, with national literature reporting 2-7% for birth injuries and international literature citing 12.4% for respiratory issues.
Purpose:
- To determine the incidence of birth injuries and respiratory diseases in term newborns.
- To compare birth-related morbidity between vaginal and abdominal delivery routes.
Summary:
- A prospective cohort study analyzed 700 term newborns (350 vaginal, 350 abdominal).
- Birth injury incidence was 5.1%, and respiratory pathology was 13.7%. Vaginal births showed significantly higher injury rates (p=0.006).
- No significant difference in respiratory disease was found between delivery routes, but C-sections preceded by labor had lower respiratory morbidity than programmed C-sections (p=0.004).
Impact:
- Vaginal delivery, particularly with forceps, is associated with increased birth injuries.
- Respiratory morbidity in newborns is not significantly different between vaginal and abdominal deliveries.
- Cesarean sections initiated after labor onset may reduce respiratory complications compared to elective procedures.
Background:
Injuries associated to tract of birth and breathing disease constitutes a risk for life and function in the perinatal period, with an incidence referred in national literature that varies from 2-7% for the first one to 12.4% in the international literature for second.
Objective:
To determine the incidence of injury associated to the tract of birth and breathing disease in newborns of term and compare the morbidity from birth among both tracts.
Material And Method:
Comparative, prospective, analytic cohort study. 350 newborns in term through vaginal tract were included, and 350 by abdominal tract. Injury associated to the tract of birth and breathing disease were analyzed.
Statistical Analysis:
for comparison among groups chi2 and t of Student, relative risk was determined.
Results:
Injury associated to the tract of birth incidence was 5.1%, breathing pathology 13.7%. The ones born by vaginal tract had an increment in the frequency of injuries compared to those born by abdominal tract (p = 0.006). There was no statistic difference in the breathing disease among both channels of birth. Nevertheless the comparison between programmed caesarean vs. caesarean preceded by labour obtained a p = 0.004.
Conclusions:
Injuries associated to birth in newborns by vaginal tract are conditioned mainly by forceps. There was no statistical significance of breathing disease when comparing both channels of birth. The caesarean preceded by labour provoked less respiratory morbility than programmed caesarean.
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