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[Nickel and magnesium effects in the rat kidney, treated with acid retinoic. Comparative study]
M D Scutariu1, Corina Ciupilan
1Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Anatomie şi Fiziologie.
Unlabelled:
Magnesium and nickel are ions with an important role in the human body, but their effects are not completely understood.
Aim:
To clarify the actions of magnesium and nickel on the rat kidney, which was experimentally treated with retinoic acid, an important therapeutic agent.
Material And Method:
The first lot of animals was the witness lot and didn't receive any substance. The second lot received retinoic acid, 50 mg/kg weight/day for 30 days. The third lot received retinoic acid in the same way and magnesium acexamate, 0.5 mEq /kg weight/day for 30 days. The fourth lot received retinoic acid in the same way and NiCl2, 0.5 mEq /kg weight/day for 30 days.
Results:
The retinoic acid has a toxic effect on the rat kidney. The magnesium decreases this toxic effect but the nickel increases this toxic effect and destroys some urinary tubes.
