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Related Experiment Video

Updated: Jul 7, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Pharmacologic strategies for combating the inflammatory response.

¹Edmund Cohen Laboratory for Vascular Research, Chronic Disease Research Centre, UWI Bridgetown, Barbados. clive.landis@uwichill.edu.bb

The Journal of Extra-Corporeal Technology

|February 26, 2008

Summary

A broad host defense response to surgery requires combinatorial or promiscuous pharmacotherapy, not a single drug. Future treatments must prioritize safety and clearly defined adverse events.

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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

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Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

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Published on: July 16, 2012

Area of Science:

Cardiovascular Surgery
Immunology
Pharmacology

Background:

Systemic inflammatory response (SIR) is a complex reaction to surgical trauma and cardiopulmonary bypass (CPB).
SIR involves activation of coagulation, fibrinolysis, immune cells, and oxidative pathways.
Localized trauma from grafts and ischemia/reperfusion further exacerbates SIR.

Purpose of the Study:

To explore pharmacotherapeutic strategies for mitigating SIR following surgery.
To evaluate the potential of combinatorial and promiscuous drug approaches.
To address the need for robust safety data in future drug development.

Main Methods:

Review of existing literature on SIR and pharmacologic interventions.
Discussion of potential drug targets within coagulation, fibrinolysis, and inflammatory pathways.
Consideration of safety profiles for anti-fibrinolytic agents.

Main Results:

No single agent can effectively manage the multifaceted SIR.
Combinatorial pharmacotherapy offers a promising strategy by targeting multiple pathways.
Promiscuous drugs, like aprotinin, can target several SIR components simultaneously.

Conclusions:

Combinatorial or promiscuous pharmacotherapy is the most viable approach to manage SIR.
Future anti-fibrinolytic therapies require strong mechanistic and safety data.
Clinical trials must focus on isolated, well-defined adverse events like stroke and renal failure.