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Hypodermis

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

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Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...

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Related Experiment Video

Updated: Jul 7, 2026

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Adipose-derived cells.

Emanuele Meliga¹, Brian M Strem, H J Duckers

¹Thoraxcenter, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.

Cell Transplantation

|February 26, 2008

Summary

This summary is machine-generated.

Adipose-derived stem cells (ADSCs) show promise for heart repair. These cells, harvested from fat tissue, are being studied for their potential to improve cardiac function after myocardial infarction.

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Last Updated: Jul 7, 2026

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Localization, Identification, and Excision of Murine Adipose Depots

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Area of Science:

Regenerative Medicine
Cardiovascular Research
Stem Cell Biology

Background:

Heart failure is a leading cause of hospitalization in Western countries.
Cell therapy offers potential for tissue regeneration in cardiac disease.
Adipose-derived stem cells (ADSCs) possess multipotent properties, including self-renewal and multilineage differentiation.

Purpose of the Study:

To explore the safety and feasibility of ADSC transplantation in patients with acute myocardial infarction (AMI).
To evaluate the therapeutic potential of ADSCs for cardiac repair and functional improvement.

Main Methods:

ADSCs express MSC markers and secrete angiogenesis-related cytokines.
Large quantities of ADSCs can be harvested from adipose tissue with minimal morbidity.
Studies in porcine AMI models demonstrated significant left ventricular (LV) functional improvement without fatal arrhythmias.

Main Results:

ADSCs exhibit developmental plasticity, including multilineage differentiation and self-renewal.
Porcine AMI models showed significant improvements in LV function post-treatment.
The APOLLO trial is a first-in-man study investigating ADSC transplantation safety and feasibility.

Conclusions:

ADSCs represent a promising cell source for cardiac regenerative medicine.
ADSC transplantation may offer a viable therapeutic strategy for patients with acute myocardial infarction.
Further clinical investigation is warranted to confirm the safety and efficacy of ADSC therapy in humans.