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In Vivo Calcium Imaging of Lateral-line Hair Cells in Larval Zebrafish
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The CaV3.1 T-type Ca2+channel contributes to voltage-dependent calcium currents in rat outer hair cells

Akira Inagaki1, Shinya Ugawa, Hisao Yamamura

  • 1Department of Otorhinolaryngology Graduate School of Medical Sciences, Nagoya City University, Nagoya, 467-8601, Japan. ainagaki@med.nagoya-cu.ac.jp

Brain Research
|February 26, 2008
PubMed

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
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The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...