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Updated: Jun 25, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

Aurora kinases as an anti-cancer target

Takayuki Ikezoe

    Cancer Letters
    |February 26, 2008
    PubMed

    Insights

    Aurora kinases are crucial for cell division and are often overexpressed in cancers. Inhibiting these kinases shows promise as a novel anti-cancer strategy.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Oncology

    Background:

    • Aurora kinases are serine/threonine kinases vital for mitotic progression.
    • Aberrant Aurora kinase expression is linked to human solid tumors and hematological malignancies, indicating a role in carcinogenesis.

    Purpose of the Study:

    • To review the function of Aurora kinases in mitosis.
    • To present the rationale for targeting Aurora kinases in cancer therapy.
    • To summarize recently developed Aurora kinase inhibitors.

    Main Methods:

    • Literature review of studies on Aurora kinase function.
    • Analysis of the role of Aurora kinases in mitosis and cancer.
    • Compilation of data on Aurora kinase inhibitors.

    Main Results:

    • Aurora kinases regulate chromosome alignment, segregation, and cytokinesis.
    • Their aberrant expression suggests a role in cancer development.
    • Various inhibitors targeting Aurora kinases have been developed.

    Conclusions:

    • Aurora kinases are critical regulators of mitosis.
    • Their involvement in carcinogenesis makes them attractive anti-cancer targets.
    • Inhibitors of Aurora kinases represent a promising therapeutic avenue.

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