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Related Experiment Video

Updated: Jul 7, 2026

High-throughput, Microscale Protocol for the Analysis of Processing Parameters and Nutritional Qualities in Maize (Zea mays L.)

High-throughput, Microscale Protocol for the Analysis of Processing Parameters and Nutritional Qualities in Maize (Zea mays L.)

Published on: June 16, 2018

A study on maize proteins as a potential new tablet excipient.

Dominique M R Georget¹, Susan A Barker, Peter S Belton

¹University of East Anglia, Norwich, UK. d.georget@uea.ac.uk <d.georget@uea.ac.uk>

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V

|February 26, 2008

Summary

Zein proteins from maize show promise as a robust matrix for oral controlled-release tablets. These zein-based formulations demonstrated stable drug release profiles, indicating potential for improved pharmaceutical applications.

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Last Updated: Jul 7, 2026

High-throughput, Microscale Protocol for the Analysis of Processing Parameters and Nutritional Qualities in Maize (Zea mays L.)

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Published on: June 16, 2018

Quantifying Plant Soluble Protein and Digestible Carbohydrate Content, Using Corn (Zea mays) As an Exemplar

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Published on: August 6, 2018

Area of Science:

Pharmaceutical Sciences
Materials Science
Biopolymers

Background:

Oral controlled-release formulations are crucial for enhancing patient compliance.
Zein proteins, derived from maize, offer potential as a primary component in such drug delivery systems.

Purpose of the Study:

To investigate the feasibility of using zein proteins as a matrix for oral controlled-release tablets.
To evaluate the impact of manufacturing processes on zein protein structure and drug release characteristics.

Main Methods:

Tablets were prepared using wet granulation and direct compression methods.
Fourier Transform infrared and Raman spectroscopy analyzed zein protein structural integrity.
Pharmacopoeial dissolution tests and the Peppas and Sahlin model assessed drug release kinetics.

Main Results:

Zein protein secondary structure (random coils, alpha helices, beta sheets) remained stable throughout processing.
Formulations exhibited robust characteristics, insensitive to minor production variations.
Limited theophylline release over 4.5 hours indicated controlled release potential.
Drug release mechanisms varied between diffusion and polymer relaxation depending on formulation and pH.

Conclusions:

Zein proteins are a viable pharmaceutical excipient for monolithic controlled-release tablets.
Zein-based formulations offer a stable and potentially effective platform for oral drug delivery.