Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...

Types of Step-Growth Polymers: Polyesters

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...

Anionic Chain-Growth Polymerization: Overview

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...

Step-Growth Polymerization: Overview

Step-Growth Polymerization: Overview

Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...

Free-Radical Chain Reaction and Polymerization of Alkenes

Free-Radical Chain Reaction and Polymerization of Alkenes

The conversion of alkenes to macromolecules called polymers is a reaction of high commercial importance. The structure of the polymer is defined by a repeating unit, while the terminal groups are considered insignificant. The average degree of polymerization represents the number of repeating units in the polymer molecule and is denoted by the subscript n.

Olefin Metathesis Polymerization: Overview

Olefin Metathesis Polymerization: Overview

Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Activation of the coagulation cascade as a mechanism for selective nanoparticle-mediated RNA delivery to the endothelium in vivo.

Science advances·2025

Same author

Corrigendum to 'The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules' [Biomaterials Volume 29 Issue 9 (2008) 5825].

Biomaterials·2025

Same author

Electrical Impedance Correlated to Flow Rate in Elastomeric Valves: An Analog Material Memory.

ACS applied materials & interfaces·2025

Same author

An In Situ Curing, Shear-Responsive Biomaterial Designed for Durable Embolization of Microvasculature.

Advanced healthcare materials·2025

Same author

Predicting Clinical Outcomes of SARS-CoV-2 Drug Efficacy with a High-Throughput Human Airway Microphysiological System.

Advanced biology·2024

Same author

Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry.

Nature materials·2024

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Amino alcohol-based degradable poly(ester amide) elastomers.

Christopher J Bettinger¹, Joost P Bruggeman, Jeffrey T Borenstein

¹Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E25-342, Cambridge, MA 02139, USA.

|February 26, 2008

Summary

This summary is machine-generated.

Researchers developed novel biodegradable poly(ester amide)s, offering improved flexibility and tunable degradation. These advanced elastomers show promise for biomedical applications due to their biocompatibility and extended in vivo half-lives.

More Related Videos

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

Published on: December 16, 2022

Related Experiment Videos

Last Updated: Jul 7, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

Published on: December 16, 2022

Area of Science:

Biomaterials Science
Polymer Chemistry
Tissue Engineering

Background:

Current synthetic biodegradable elastomers, often aliphatic polyesters, exhibit limitations such as high stiffness, rapid degradation, and restricted chemical modification.
These deficiencies hinder their broad application in areas requiring specific mechanical properties and controlled degradation profiles.

Purpose of the Study:

To synthesize and characterize a new class of biodegradable elastomeric poly(ester amide)s.
To address the limitations of existing biodegradable elastomers by developing materials with tunable mechanical properties and degradation rates.

Main Methods:

Synthesis of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s via crosslinked networks based on an amino alcohol.
Evaluation of mechanical properties, including tensile Young's modulus and reversible elongation.
Assessment of in vitro and in vivo biocompatibility and degradation profiles.

Main Results:

The novel poly(ester amide)s demonstrated a tensile Young's modulus on the order of 1MPa and reversible elongations up to 92%.
The polymers exhibited excellent in vitro and in vivo biocompatibility.
Projected degradation half-lives in vivo were up to 20 months, indicating controlled degradation.

Conclusions:

The developed poly(ester amide)s represent a promising new class of biodegradable elastomers.
These materials overcome key limitations of existing elastomers, offering improved mechanical properties and tunable degradation for biomedical applications.