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Published on: October 10, 2020
Synthesis of curcumin mimics with multidrug resistance reversal activities
Yumi Um1, Sungsik Cho, Ho Bum Woo
1College of Medicine, Kwandong University, Gangneung 210-701, Republic of Korea.
Abstract:
In order to discover novel multidrug resistance (MDR) reversal agents for efficient cancer chemotherapy, the unsymmetrical curcumin mimics with various amide moieties (6-19) were synthesized and evaluated their MDR reversal activities in MDR cell line KBV20C. Among the tested compounds, 13, 16, and 17 showed potent MDR reversal activities by inhibiting drug efflux function of P-glycoprotein in KB20C cells, and almost recovered the cytotoxicity of vincristine and paclitaxel against KBV20C cell to the degree of potency against drug sensitive KB cells.
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