Synthesis, DNA binding and cleavage activities of the copper (II) complexes of estrogen-macrocyclic polyamine

Xin-Bin Yang1, Jie Feng, Ji Zhang

  • 1Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, No. 29, Wangjiang Road, Chengdu, Sichuan 610064, PR China.

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In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...