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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
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Stem cell trafficking in tissue development, growth, and disease.

Diana J Laird1, Ulrich H von Andrian, Amy J Wagers

  • 1Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10058, USA.

Cell
|February 26, 2008
PubMed
Summary

Stem cell trafficking is vital for development, repair, and therapies. Understanding these migration mechanisms across various stem cell types can advance cell-based treatments and drug delivery.

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Regulated stem cell movement is essential for organ formation during development.
  • Stem cell trafficking plays a crucial role in maintaining tissue homeostasis and facilitating repair in adult organisms.
  • Understanding stem cell migration is key to unlocking their therapeutic potential.

Purpose of the Study:

  • To analyze the biological significance of stem cell trafficking.
  • To elucidate the molecular mechanisms governing stem cell migration.
  • To compare stem cell homing and migration across different cell types and organisms.

Main Methods:

  • Comparative analysis of stem cell trafficking across various biological systems.
  • Investigation of molecular mechanisms underlying stem cell homing and migration.
  • Review of in vivo trafficking in the context of therapeutic applications.

Main Results:

  • Stem cell trafficking is conserved yet specialized across diverse lineages, including germline, blood, and muscle stem cells.
  • Mechanisms of homing and migration are shared among leukocytes, adult/fetal stem cells, and cancer stem cells.
  • In vivo trafficking is fundamental to hematopoietic stem cell transplantation success.

Conclusions:

  • Elucidating stem cell migration pathways is critical for advancing cell therapy and targeted drug delivery.
  • Further research into stem cell homing mechanisms will broaden therapeutic applications.
  • Stem cell trafficking represents a fundamental biological process with significant clinical implications.