Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scleroderma-like disorders.

R Foti1, R Leonardi, R Rondinone

  • 1Rheumatology Unit, Azienda Ospedaliera Universitaria V. Emanuele, Ferrarotto, S. Bambino Catania, Italy.

Autoimmunity Reviews
|February 26, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Light Long-Lived Particles in pp Collisions at sqrt[s]=13  TeV Using Displaced Vertices in the ATLAS Inner Detector.

Physical review letters·2024
Same author

Search for the Exclusive W Boson Hadronic Decays W^{±}→π^{±}γ, W^{±}→K^{±}γ and W^{±}→ρ^{±}γ with the ATLAS Detector.

Physical review letters·2024
Same author

Determination of the Relative Sign of the Higgs Boson Couplings to W and Z Bosons Using WH Production via Vector-Boson Fusion with the ATLAS Detector.

Physical review letters·2024
Same author

Studies of the Energy Dependence of Diboson Polarization Fractions and the Radiation-Amplitude-Zero Effect in WZ Production with the ATLAS Detector.

Physical review letters·2024
Same author

Combination of Searches for Higgs Boson Pair Production in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2024
Same journal

Decoding gut microbiome alterations in celiac disease: Implications for pathogenesis and treatment.

Autoimmunity reviews·2026
Same journal

Rethinking immunosuppression in limited cutaneous systemic sclerosis. The lcSSc conundrum; pros and cons for a timely immunosuppressive treatment.

Autoimmunity reviews·2026
Same journal

Kidney failure in patients with ANCA-associated vasculitis: A systematic review of outcomes.

Autoimmunity reviews·2026
Same journal

The role of antimicrobial peptides in rheumatoid arthritis: From mucosal predisposition to chronic synovitis.

Autoimmunity reviews·2026
Same journal

The role of short-chain fatty acids as key mediators of gut microbiota - host crosstalk in thyroid diseases.

Autoimmunity reviews·2026
Same journal

Intermittent hydrarthrosis (periodic synoviosis): A narrative review.

Autoimmunity reviews·2026
See all related articles

Fibrosing disorders are a diverse group of diseases causing skin thickening, similar to systemic sclerosis. Accurate diagnosis of these scleroderma-like conditions is crucial for effective treatment.

Area of Science:

  • Rheumatology
  • Dermatology
  • Pathology

Background:

  • Fibrosing disorders are a heterogeneous group of diseases characterized by sclerosis affecting the dermis, subcutis, and potentially deeper tissues.
  • These conditions present with skin thickening, often described as "scleroderma-like" due to similarities with systemic sclerosis, but with distinct distribution patterns.
  • The clinical spectrum ranges from localized cutaneous involvement to severe, systemic, life-threatening manifestations, sometimes associated with autoimmunity.

Purpose of the Study:

  • To highlight the importance of recognizing the spectrum of fibrosing disorders.
  • To differentiate these conditions from systemic sclerosis based on distribution patterns.
  • To emphasize the need for accurate diagnosis for appropriate therapeutic strategies.

Main Methods:

Related Experiment Videos

  • Review of clinical characteristics of fibrosing disorders.
  • Comparison of clinical presentation with systemic sclerosis.
  • Analysis of disease course and associated autoimmune features.

Main Results:

  • Fibrosing disorders exhibit variable clinical courses and severity.
  • Scleroderma-like features are present but differ in distribution from systemic sclerosis.
  • Association with autoantibodies and autoimmune conditions is noted in some cases.

Conclusions:

  • Accurate identification of fibrosing disorders is essential for patient management.
  • Understanding the heterogeneity of these conditions guides treatment decisions.
  • Prompt diagnosis facilitates the institution of the most appropriate therapeutic interventions.