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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound
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Needle size and injection rate impact microbubble contrast agent population.

Esra Talu1, Robert L Powell, Marjorie L Longo

  • 1Department of Chemical Engineering & Materials Science, Davis, CA, USA.

Ultrasound in Medicine & Biology
|February 26, 2008
PubMed
Summary

Ultrasound contrast microbubbles are sensitive to pressure. Injecting them through small catheters can alter their concentration and size, impacting imaging quality.

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Published on: June 12, 2021

Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Acoustics

Background:

  • Microbubbles are common ultrasound contrast agents, crucial for image enhancement.
  • Their compressibility makes them sensitive to pressure changes, beneficial for imaging but prone to destruction.
  • Small-gauge catheter injection, used in small animal studies, can compromise microbubble integrity.

Purpose of the Study:

  • To investigate the impact of catheter diameter on microbubble integrity during injection.
  • To analyze alterations in microbubble concentration and size distribution post-injection.

Main Methods:

  • Microbubbles were injected through catheters of varying diameters.
  • Concentration and size distribution of microbubbles were analyzed post-injection.

Main Results:

  • Injection through small-gauge needles, especially with rapid administration, significantly affects microbubble properties.
  • Catheter diameter and injection speed are critical factors influencing microbubble concentration and size distribution.

Conclusions:

  • Careful consideration of injection parameters is necessary to maintain microbubble integrity for accurate ultrasound imaging.
  • Findings are particularly relevant for small animal imaging studies utilizing microbubble contrast agents.