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Updated: Jul 7, 2026
09:33
Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
Published on: March 20, 2026
Angiogenesis in gliomas
Agnieszka Lebelt1, Janusz Dziecioł, Katarzyna Guzińska-Ustymowicz
1Department of Human Anatomy, Medical University, Białystok, Poland. anatomia@amb.edu.pl
Folia Histochemica Et Cytobiologica
|February 26, 2008
Summary
This study found that brain glioma vascularization, measured by microvascular proliferation and density, correlates with malignancy grade. Higher vascularization was seen in aggressive glioblastomas, indicating its prognostic value.
Area of Science:
- Neuro-oncology
- Pathology
- Cancer Biology
Background:
- Brain gliomas exhibit invasive growth and neovascularization.
- Angiogenesis is crucial for glioma progression and has prognostic significance.
Purpose of the Study:
- To assess brain glioma vascularization.
- To correlate vascularization with histological type, malignancy grade, location, size, patient age, and sex.
Main Methods:
- Tumor vascularization assessed via microvascular proliferation (MVP) and microvessel density (MVD).
- Immunohistochemistry used Ki-67, PCNA (proliferation markers), CD31, and anti-human von Willebrand factor (vessel markers).
Main Results:
- Highest MVP and MVD observed in glioblastomas multiforme.
- Lowest MVP and MVD found in oligodendrogliomas.
- Significant correlation between vascularization and malignancy grade.
Conclusions:
- Brain glioma vascularization, particularly MVP and MVD, is linked to malignancy grade.
- Vascularization patterns differ significantly among glioma subtypes.
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