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Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
Introduction to Electrolytes01:33

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Related Experiment Video

Updated: Jul 7, 2026

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
12:30

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

Current calcium recommendations in North America.

Connie M Weaver1

  • 1Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907-2059, USA. weavercm@purdue.edu

Asia Pacific Journal of Clinical Nutrition
|May 28, 2008
PubMed
Summary

North American calcium recommendations from 1997 aimed for maximal retention to support bone health. Current research suggests optimal calcium intake for retention may be consistent across diverse groups, despite differing retention levels.

Area of Science:

  • Nutritional Science
  • Bone Metabolism
  • Public Health Nutrition

Background:

  • Established North American calcium recommendations (1997) focused on maximizing calcium retention for bone health.
  • Bone density is linearly related to fracture risk, and 99% of calcium is stored in bones.
  • Previous recommendations often relied on limited data, typically for a single gender and race within age groups.

Purpose of the Study:

  • To evaluate the assumption that maximizing calcium retention is the optimal goal for bone health.
  • To investigate whether calcium intakes for maximal retention differ across demographic subgroups.
  • To address current issues in calcium intake research, including catch-up growth, dairy versus calcium sources, and optimal intake determination.

Main Methods:

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Assessment of Calcium Sparks in Intact Skeletal Muscle Fibers
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Assessment of Calcium Sparks in Intact Skeletal Muscle Fibers

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Related Experiment Videos

Last Updated: Jul 7, 2026

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
12:30

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
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Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry

Published on: October 28, 2014

Assessment of Calcium Sparks in Intact Skeletal Muscle Fibers
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Assessment of Calcium Sparks in Intact Skeletal Muscle Fibers

Published on: February 24, 2014

  • Review of existing scientific evidence regarding calcium retention and its relationship with bone health.
  • Analysis of data suggesting potential consistency in maximal calcium retention intakes across different subgroups.
  • Consideration of emerging research on factors influencing calcium balance and bone metabolism.

    • Main Results:

    • Recent evidence indicates that calcium intakes required for maximal retention may not significantly vary between different demographic subgroups.
    • Despite potential consistency in optimal intake levels, actual calcium retention can differ substantially among individuals at any given intake.
    • The study highlights ongoing debates concerning catch-up growth, the role of dairy products versus total calcium intake, and methods for establishing optimal calcium requirements.

    Conclusions:

    • The 1997 approach of setting calcium recommendations based on maximal retention may need re-evaluation in light of new evidence.
    • Optimal calcium intake levels for maximizing retention might be more universal than previously assumed, irrespective of subgroup differences in retention.
    • Further research is crucial to refine calcium intake guidelines, considering factors like catch-up growth and the source of calcium.