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Updated: Jul 7, 2026

Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis
Published on: June 15, 2011
Mechanisms of venous thrombosis and resolution
Thomas W Wakefield1, Daniel D Myers, Peter K Henke
1Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. thomasww@umich.edu
Abstract:
Venous thromboembolism is a significant health care problem in the US. In this review, the unique role of inflammation to the venous thrombotic process is emphasized as well as the potential role of abnormalities of fibrinolytic mechanisms to the thrombotic process. Inflammation influences not only thrombogenesis but also thrombus resolution and vein wall remodeling, and these interactions are also discussed. Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies.
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