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Physical and functional interactions between STAT5 and Runx transcription factors

Shinya Ogawa1, Masanobu Satake, Koichi Ikuta

  • 1Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.

Journal of Biochemistry
|February 26, 2008
PubMed
Summary

Signal transducers and activators of transcription (STAT) and Runt-related (Runx) proteins interact, mutually inhibiting transcriptional activity. This STAT5-Runx interaction may play a role in lymphocyte development.

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