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Decrease in intestinal endocrine cells in Balb/c mice with CT-26 carcinoma cells
Kwang-Ho Cho1, Hyeung-Sik Lee, Sae-Kwang Ku
1Department of Radiological Science, College of Health Science, Catholic University of Daegu, Daegu 712-702, Korea.
Abstract:
The density of intestinal endocrine cells, in Balb/c mice with colon 26 (CT-26) carcinoma cells, were examined immunohistochemically at 28 days after implantation. After CT-26 cell administration there was a significant decrease in most of the intestinal endocrine cells (p < 0.01) compared with the control group. The significant quantitative changes in the intestinal endocrine cell density might contribute to the development of the gastrointestinal symptoms commonly encountered in cancer patients.
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