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Published on: January 4, 2015
Stem cells: therapeutic present and future
Abstract:
Ever since the first embryonic stem cells were isolated in the 1990s scientists and clinicians as well as the general public have followed the development of the field with great attention. As unspecialized cells capable of dividing, renewing and differentiating into specialized cells, stem cells hold great promise as a therapeutic strategy for many diseases, especially those of degenerative nature. In 2006, stem cells were actively investigated in preclinical and clinical settings to manage heart failure, amyotrophic lateral sclerosis, spinal cord injury, stroke, hematologic disorders, renal cell carcinoma, solid tumor cancer, Crohn's disease and cirrhosis, among other disorders. Likewise, biotech and pharmaceutical industry highlighted stem cells and associated products and technologies as useful tools for drug discovery that provide relevant clinical models and ensure efficacious transition of investigational compounds into preclinical testing.
Insights
Stem cells, unspecialized cells with therapeutic potential, are being investigated for degenerative diseases and drug discovery. Their ability to renew and differentiate offers promise for treating conditions like heart failure and cancer.
Area of Science:
- Regenerative Medicine
- Biotechnology
Background:
- Embryonic stem cells, isolated in the 1990s, are unspecialized cells with self-renewal and differentiation capabilities.
- Stem cells offer significant therapeutic promise for degenerative diseases.
Purpose of the Study:
- To explore the therapeutic applications of stem cells in various degenerative diseases.
- To highlight the role of stem cells in drug discovery and preclinical testing.
Main Methods:
- Active investigation in preclinical and clinical settings.
- Utilizing stem cells as tools for drug discovery and clinical models.
Main Results:
- Stem cells are being investigated for heart failure, ALS, spinal cord injury, stroke, and more.
- The biotech and pharmaceutical industries recognize stem cells for drug discovery and preclinical testing.
Conclusions:
- Stem cell research continues to advance, holding promise for treating a wide range of diseases.
- Stem cells are valuable tools in pharmaceutical development, aiding in the transition of compounds to clinical trials.
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