Related Experiment Video
Updated: Aug 18, 2026

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
Published on: October 24, 2018
Adolescent offspring of endogenous unipolar depressive parents and of normal parents
M Grigoroiu-Serbănescu1, D Christodorescu, S Măgureanu
1Institute of Neurology and Psychiatry, Bucharest, Romania.
Abstract:
Ninety-six children aged 10-17 of unipolar endogenous depressive proband parents and 96 matched control children of well parents were investigated using DSM-IIIR diagnostic criteria. Both sets of parents were also studied. Although the rate of psychopathology was significantly higher in proband than in control children, adaptive functioning as a measure of the severity of the psychopathology did not differentiate the two groups of children. Among factors related to the mental status of the children were: severity and onset under 30 years of age of the parental depression and lifelong association of parental anxiety with depression. Personality measurements performed in children showed different personality structures in proband offspring. Data on adolescent psychopathology and personality showed little evidence of a homotypic relationship with the adult affective disorders.
Related Concept Videos
Law of Segregation
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Depression: Overview
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Influence of Parents and Peers on Identity
Parental Influence on Identity Development
Parents serve as primary guides and managers in an adolescent's life, offering support instrumental in decision-making and personal growth. This guiding role...
Oppositional Defiant Disorder
Diagnostic Criteria and...

