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Updated: Jul 7, 2026

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
Published on: January 11, 2019
[Male antifertility drugs and cell apoptosis]
Shu-Wei Zha1, Ji Zha, Yu-Feng Huang
1Jiangsu Family Planning Research Institute, Nanjing, Jiangsu 210036, China. zhaji423@tom.com
Abstract:
Male antifertility drugs can induce contraception by interfering with spermatogenesis progression. Their action mechanism is correlated with the apoptosis of spermatogenic cells. This paper summarizes recent researches on the mechanism of male antifertility-drugs, including testosterone, gossypol, tamoxifen and triptolide, reviews their regulating effect on cell apoptosis and the expression of the key genes and proteins involved, and explores the significance of further researches on male antifertility drugs and cell apoptosis.
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