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Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...

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Related Experiment Video

Updated: Jul 7, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
10:33

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Quantification of chemical mixture interactions modulating dermal absorption using a multiple membrane fiber array.

Ronald E Baynes1, Xin Rui Xia, Mudassar Imran

  • 1Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA. Ronald_Baynes@ncsu.edu

Chemical Research in Toxicology
|February 27, 2008
PubMed
Summary
This summary is machine-generated.

Chemical mixtures alter skin absorption by changing physicochemical interactions. A three-membrane-coated fiber array effectively predicts these dermal permeability changes, showing its utility for assessing toxicant bioavailability.

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Area of Science:

  • Toxicology
  • Physical Chemistry
  • Materials Science

Background:

  • Dermal exposure to chemical mixtures can alter the systemic bioavailability of toxicants.
  • Physicochemical interactions between mixtures, skin, and solutes influence dermal permeability.
  • Abraham's linear solvation energy relationship (LSER) describes these interactions via system coefficients and molecular descriptors.

Purpose of the Study:

  • To evaluate the impact of solvent (ethanol) and surfactant (sodium lauryl sulfate, SLS) mixtures on solute permeability and partitioning.
  • To quantify changes in system coefficients within both skin and a three-membrane-coated fiber (MCF) system.
  • To correlate changes in system coefficients between the MCF array and skin to predict dermal absorption.

Main Methods:

  • Utilized a three-membrane-coated fiber (MCF) array, including PDMS and WAX fibers, to mimic skin.
  • Exposed the MCF array and skin models to mixtures containing ethanol (50%) or SLS (1%).
  • Quantified changes in system coefficients using Abraham's linear solvation energy relationship (LSER).
  • Employed regression analysis to correlate changes in system coefficients between the two systems.

Main Results:

  • Strong correlations (R² = 0.89–0.98) were observed between system coefficient changes in skin and the MCF array when exposed to SLS or ethanol mixtures.
  • The PDMS fiber significantly contributed to predicting solute permeability changes in the MCF array (R² = 0.84–0.85).
  • The WAX fiber showed a lesser, though still relevant, contribution (R² = 0.59–0.77).

Conclusions:

  • The MCF array effectively predicts changes in dermal permeability caused by mixtures containing surfactants or solvents.
  • Physicochemical interactions within the MCF array correlate well with those occurring in skin under mixture exposure.
  • This study highlights the utility of the MCF array for understanding and predicting dermal absorption modulation by chemical mixtures.