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Updated: Jul 7, 2026
Production of Nanofibrillar Patterned Collagen for Tissue Engineering
Published on: September 20, 2024
Fabrication, characterization, and application in surface-enhanced Raman spectrum of assembled type-I collagen-silver
Yujing Sun1, Li Wang, Lanlan Sun
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, China.
Abstract:
In this paper, we report a facile method for the fabrication of type-I collagen-silver nanoparticles (Ag NPs) multilayered films by utilizing type-I collagen as a medium. These samples were characterized by UV-vis spectra photometer, atomic force microscopy, scanning electron microscopy, and Fourier transform IR spectrum. Experimental results show that collagen molecules serve as effective templates to assemble Ag NPs into multilayer films. These samples exhibit high surface-enhanced Raman scattering (SERS) enhancement abilities. For example, EF(nu(cc)) (EF means enhancement factor) at 1592 cm(-1) in the SERS spectrum of 4-aminothiophenol on seven-layered substrates was calculated to be 1.81 x 10(5), which is larger than that reported in several literatures. The EFs increased as the layer number of multilayer films increases.
