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Reference intervals for circulating angiogenic cytokines.

Sun-Young Kong1, Hye Lin Lee, Hyeon-Seok Eom

  • 1Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea. ksy@ncc.re.kr

Clinical Chemistry and Laboratory Medicine
|February 27, 2008
PubMed
Summary

Reference intervals for angiogenic cytokines like vascular endothelial growth factor (VEGF) were established. Cytokine levels generally do not correlate with genetic variations, except for serum VEGF, which is influenced by a specific polymorphism.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Angiogenic cytokines are crucial for cancer characterization and prognosis.
  • Establishing reference intervals for these cytokines is essential but underexplored.
  • Key cytokines studied include VEGF, HGF, bFGF, IL-6, VEGFR1, and VEGFR2.

Purpose of the Study:

  • To determine reference intervals for key angiogenic cytokines in biological samples.
  • To investigate the relationship between angiogenic cytokine levels and genetic polymorphisms.

Main Methods:

  • Quantification of angiogenic cytokines in serum, plasma, and urine from 131 healthy controls.
  • Analysis of associations between cytokine levels and other laboratory parameters.
  • Exploration of the impact of gene polymorphisms on cytokine concentrations.

Main Results:

  • Reference intervals for the selected angiogenic cytokines were successfully established.
  • Cytokine concentrations showed minimal variation with genotype or haplotype across most factors.
  • Serum VEGF concentration was found to be marginally influenced by the -1154 VEGF polymorphism.

Conclusions:

  • The study provides essential reference intervals for angiogenic cytokines.
  • Genetic polymorphisms generally do not significantly alter angiogenic cytokine levels.
  • Serum VEGF represents an exception, showing a slight dependence on the -1154 VEGF polymorphism.