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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Microemulsions: applications in transdermal and dermal delivery
Abhijit A Date1, V B Patravale
1Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz, Mumbai, India.
Critical Reviews in Therapeutic Drug Carrier Systems
|February 27, 2008
Summary
Microemulsions offer enhanced topical drug delivery due to their formation ease and high capacity. This review details excipients and mechanisms for improved dermal and transdermal delivery of hydrophilic and lipophilic drugs.
Area of Science:
- Pharmaceutical Sciences
- Colloid Science
- Drug Delivery Systems
Background:
- Microemulsions are advanced colloidal carriers for drug delivery.
- They offer advantages like spontaneous formation, manufacturing ease, high drug solubility, and enhanced stability.
- These systems are suitable for both hydrophilic and lipophilic drugs.
Purpose of the Study:
- To review excipients used in topical microemulsion formulations.
- To explore mechanisms enhancing dermal/transdermal drug delivery via microemulsions.
- To summarize in vitro and in vivo studies of therapeutic agents delivered by microemulsions.
Main Methods:
- Literature review of scientific publications.
- Analysis of formulation components (excipients).
- Examination of drug permeation and efficacy studies.
Main Results:
- Identification of key excipients for topical microemulsions.
- Elucidation of mechanisms driving improved drug penetration and stability.
- Compilation of data on various therapeutic agents delivered via microemulsions.
Conclusions:
- Microemulsions represent a versatile platform for topical and transdermal drug delivery.
- Careful selection of excipients and understanding of mechanisms are crucial for optimizing delivery.
- Ongoing research continues to advance microemulsion applications in therapeutics.
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