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Published on: December 11, 2017
Coronary sinus side branches for cardiac resynchronization therapy: prospective evaluation of availability, implant
Gabor Z Duray1, Stefan H Hohnloser, Carsten W Israel
1Department of Medicine, Division of Cardiology, Section Clinical Electrophysiology, J. W. Goethe University, Frankfurt, Germany.
Insights
Cardiac resynchronization therapy (CRT) patients often have multiple coronary side branches (CS-SB) suitable for LV lead implantation. Successful implantation in the first choice CS-SB occurs in 71% of cases.
Area of Science:
- Cardiology
- Medical Devices
- Electrophysiology
Background:
- Limited data exists on coronary side branch (CS-SB) anatomy for left ventricular (LV) lead implantation in cardiac resynchronization therapy (CRT).
- Understanding CS-SB availability is crucial for successful CRT device implantation.
Purpose of the Study:
- To investigate the anatomy of coronary side branches (CS-SB) for left ventricular (LV) lead implantation in patients undergoing cardiac resynchronization therapy (CRT).
- To determine the success rates and procedural variables associated with LV lead implantation in various CS-SBs.
Main Methods:
- Detailed venograms were obtained in patients undergoing CRT device implantation.
- Coronary side branches (CS-SB) were categorized by choice (first, second, third, fourth) for LV lead implantation.
- Study endpoints included LV lead implantation success, number of available CS-SBs, procedural times, and 6-month CRT response.
Main Results:
- In 77% of patients, 3 or 4 suitable CS-SBs were available for LV lead implantation.
- Successful LV lead implantation in the first choice CS-SB was achieved in 71% of patients.
- Implantation in the first choice CS-SB was associated with shorter procedure and fluoroscopy times compared to subsequent choices.
Conclusions:
- At least three suitable CS-SBs are available in most patients undergoing CRT device implantation.
- First choice CS-SB implantation success is 71% and is not significantly influenced by the specific CS-SB region.
Introduction:
There are only sparse data concerning individual coronary side branch (CS-SB) anatomy with respect to LV lead implantation for cardiac resynchronization therapy (CRT).
Methods:
In patients (pts) undergoing CRT device implantation, a detailed venogram was obtained, and the CS-SB of first, second, third, and fourth choices for CS-lead implantation was defined. Study endpoints included successful LV lead implantation in the first choice CS-SB, number of CS-SB potentially available, implantation success in selected CS-SB, procedural variables, and 6-month response to CRT.
Results:
CRT defibrillator implantation was attempted in 77 pts. Only 1 suitable CS-SB was present in 3 (4%), 2 in 20 (26%), 3 in 36 (47%), and 4 CS-SB in 18 patients (23%). The LV lead was implanted in the first choice CS-SB in 71% of patients, in the second choice in 16%, in the third choice in 3%. In 4 patients (5%) no LV lead could be implanted. Implant success was similar for different CS-SB regions (P = ns). Successful LV lead implantation in the CS-SB of first choice was associated with median fluoroscopy and procedure times of 20 +/- 13 and 143 +/- 41 minutes. Corresponding times for the CS-SB of >or= second choice were 38 +/- 21 (P = 0.002) and 179 +/- 47 minutes (P = 0.002). Response rate at 6 months was 64% for patients with LV leads in the first target CS-SB.
Conclusions:
In 70% of patients undergoing CRT device implantation, at least three suitable CS-SBs are available. Implant success in the CS-SB of first choice is 71% without significant differences for any particular CS-SB region.
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