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Longitudinal study of the growth of infants with isolated Robin sequence considered being severe cases

Ilza L Marques1, Heloísa Bettiol, Luiz de Souza

  • 1Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo (HRAC-USP), Brazil. marquesi@usp.br

Acta Paediatrica (Oslo, Norway : 1992)
|February 27, 2008
PubMed

Insights

Infants with severe isolated Robin sequence (IRS) experienced impaired growth in weight and length during their first six months. This malnutrition persisted despite interventions like specialized feeding techniques and hypercaloric diets.

Area of Science:

  • Pediatrics
  • Genetics
  • Developmental Biology

Background:

  • Isolated Robin sequence (IRS) is a congenital anomaly affecting infant development.
  • Severe cases of IRS present significant challenges in infant care and growth.
  • Early identification and intervention are crucial for managing IRS.

Purpose of the Study:

  • To assess the growth patterns of infants diagnosed with severe isolated Robin sequence (IRS).
  • To evaluate infant growth during the first six months of life.
  • To compare growth metrics against established reference standards.

Main Methods:

  • A prospective longitudinal study followed twenty infants with severe IRS.
  • Interventions included airway disobstruction, feeding facilitation, and hypercaloric diets.
  • Weight and length were measured at birth and every two months until six months of age.

Main Results:

  • Infants with severe IRS exhibited significantly impaired weight and length growth from birth to six months.
  • Growth parameters were below the NCHS2000 reference standards.
  • The study identified persistent growth deficits in this cohort.

Conclusions:

  • Malnutrition remains a significant issue for infants with severe IRS in the first six months.
  • Standard interventions, including specialized diets and feeding techniques, were insufficient to overcome growth impairment.
  • Further research into novel therapeutic strategies for severe IRS is warranted.
Abstract

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