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Related Concept Videos

The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the timing and level of...
Organization of Genes02:07

Organization of Genes

Overview
Organization of Genes02:07

Organization of Genes

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Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

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Related Experiment Video

Updated: Jul 7, 2026

An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

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Published on: April 21, 2023

Links between core promoter and basic gene features influence gene expression.

Sandra Moshonov1, Rofa Elfakess, Michal Golan-Mashiach

  • 1Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel. sandra.moshonov@weizmann.ac.il

BMC Genomics
|February 27, 2008
PubMed
Summary
This summary is machine-generated.

Gene expression diversity arises from promoter type and gene size. Variations in TATA box sequences influence gene length, impacting expression levels and protein production efficiency.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Gene expression rate diversity is crucial for cellular functions.
  • Understanding gene expression regulation aids in comprehending normal and pathological cell activities.
  • Identifying general mechanisms controlling gene expression is key for improving expression systems.

Purpose of the Study:

  • To analyze the relationship between general gene features and their contribution to expression levels.
  • To investigate how core promoter type and gene size influence gene expression diversity.

Main Methods:

  • Genes were categorized into four groups based on core promoter type.
  • Statistical analysis of gene characteristics was performed.
  • Relationships between TATA box variations, gene length, intron size, and expression levels were examined.

Main Results:

  • Small TATA box variations correlate with significant gene length differences; canonical TATA genes are short, while non-canonical/TATA-less genes are long.
  • Gene length differences are mainly due to intron size and number.
  • Gene expression strongly correlates with TATA box strength, with reductions observed in long TATA-containing genes.
  • Intron length minimally affects TATA-less gene expression.
  • TATA-containing genes exhibit features of higher translation efficiency.

Conclusions:

  • The interplay between core promoter type and gene size significantly contributes to the diversity of gene expression.
  • These findings offer insights into the regulatory mechanisms governing gene expression and protein production.