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Updated: Jul 7, 2026
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical
Ke-hung Tsui1, Horng-heng Juang, Tsong-hai Lee
1Chang Gung Bioinformatics Center, Department of Urology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kwei-Shan, Taiwan, China.
Aim:
To investigate the possible correlation of nucleophosmin/B23 expression with bladder carcinoma recurrence.
Methods:
Surgically-resected bladder tumors staged pTa to pT4 were examined for nucleophosmin/B23 expression by immuno-histochemistry. The study group consisted of 132 consecutive patients surgically treated at Chang Gung Memorial Hospital between December 1998 and November 1999. The mean follow up was 72 months (range: 48-84 months).
Results:
Nuclear nucleophosmin/B23 staining was detected in 96% of advanced stage and poorly-differentiated tumors. Higher nucleophosmin/B23 levels were linked to more advanced tumor stages, grades, poor prognosis, and likelihood of recurrence (P<0.05). The Cox multivariate analysis indicated the nucleophosmin/B23 expression as an independent indicator for tumor recurrence (P=0.009).
Conclusion:
The results suggest that nucleophosmin/B23 is a favorable prognostic indicator for bladder cancer. Nucleophosmin/B23 could be a useful molecular tumor marker for predicting bladder cancer recurrence.
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