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Neonatal immune development in the calf and its impact on vaccine response
Christopher C L Chase1, David J Hurley, Adrian J Reber
1Department of Veterinary Science, PO Box 2175, South Dakota State University, Brookings, SD 57007, USA. christopher.chase@sdstate.edu
The Veterinary Clinics of North America. Food Animal Practice
|February 27, 2008
Abstract:
In this article we cover the immunologic response as it develops, the components of passive immunity, and the immune response of young calves. We discuss interference from maternal immunity in the development of specific immunity and vaccine strategies for developing protection against pathogens in calves.
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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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