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Persistent pupillary membranes in 3 siblings.

Ayça Sari1, Ufuk Adigüzel, Münevver Yeşilli

  • 1Mersin University School of Medicine, Mersin, Turkey. docayc@yahoo.com

Journal of Cataract and Refractive Surgery
|February 27, 2008
PubMed
Summary

Familial isolated persistent pupillary membranes, a rare condition, were observed in three siblings. This case suggests a potential genetic link for isolated persistent pupillary membranes, differing from typical sporadic occurrences.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatric eye care

Background:

  • Persistent pupillary membranes (PPM) are congenital iris remnants, typically sporadic.
  • While often asymptomatic, severe PPM can cause visual impairment.
  • Associated anterior chamber anomalies suggest potential autosomal dominant inheritance patterns.

Observation:

  • Three siblings from a nonconsanguineous family presented with bilateral persistent pupillary membranes.
  • The severity of the condition varied among the siblings.
  • One sibling required surgical intervention for pupillary axis occlusion and decreased visual acuity.

Findings:

  • This is the first reported case of familial isolated persistent pupillary membranes without other anterior segment abnormalities.

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  • The findings challenge the assumption that isolated PPM are exclusively sporadic.
  • The familial occurrence suggests a possible inherited component for isolated PPM.

    • Implications:

    • This case highlights the potential for genetic inheritance in isolated persistent pupillary membranes.
    • Further research into the genetic basis of PPM is warranted.
    • Understanding familial patterns can aid in early diagnosis and management of affected individuals.