Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Engineering custom-designed osteochondral tissue grafts.

Warren L Grayson1, Pen-Hsiu Grace Chao, Darja Marolt

  • 1Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

Trends in Biotechnology
|February 27, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic effects of hypoxia and morphogenetic factors on early chondrogenic commitment of human embryonic stem cells in embryoid body culture.

Stem cell reviews and reports·2015
Same author

Delivery of chondroitinase ABC and glial cell line-derived neurotrophic factor from silk fibroin conduits enhances peripheral nerve regeneration.

Journal of tissue engineering and regenerative medicine·2014
Same author

Silk electrogel coatings for titanium dental implants.

Journal of biomaterials applications·2014
Same author

Silk-based resorbable electronic devices for remotely controlled therapy and in vivo infection abatement.

Proceedings of the National Academy of Sciences of the United States of America·2014
Same author

Cell-tethered ligands modulate bone remodeling by osteoblasts and osteoclasts.

Advanced functional materials·2014
Same author

Multifunctional spider silk polymers for gene delivery to human mesenchymal stem cells.

Journal of biomedical materials research. Part B, Applied biomaterials·2014
Same journal

Bacterial spores as a modular platform for the production of amyloids for materials.

Trends in biotechnology·2026
Same journal

The oriGen case and Mexico's regulatory blind spots in genomic biobanking.

Trends in biotechnology·2026
Same journal

A caspase-3-activated protein expression system for apoptosis visualization and apoptosis-pyroptosis conversion to boost antitumor activity.

Trends in biotechnology·2026
Same journal

Over 4 months of ethylene production using solid-state photosynthetic cell factories.

Trends in biotechnology·2026
Same journal

Closing the nitrogen loop in groundwater with biohybrid technologies.

Trends in biotechnology·2026
Same journal

Engineering environmental bacteria for whole-cell PET hydrolysis and assimilation.

Trends in biotechnology·2026
See all related articles

Tissue engineering aims to restore organ function with custom tissue grafts. Research focuses on creating functional grafts for joint repair, addressing degenerative joint disease and disability.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedics

Background:

  • Degenerative joint disease is a leading cause of disability, affecting 20% of the US population.
  • Current research focuses on developing functional tissue grafts for joint repair.
  • Tissue engineering utilizes living cells, biomaterial scaffolds, and bioreactors for tissue regeneration.

Purpose of the Study:

  • To review the requirements for engineering customized, anatomically-shaped, stratified tissue grafts for joint repair.
  • To discuss the challenges in designing grafts for immediate functionality and long-term regeneration.

Main Methods:

  • Review of current literature on tissue engineering for joint repair.
  • Analysis of requirements for graft design, including cell sources, scaffolds, and bioreactor systems.

Related Experiment Videos

  • Discussion of challenges related to graft functionality, integration, and remodeling.

    • Main Results:

    • Engineering customized, anatomically-shaped, stratified grafts is crucial for effective joint repair.
    • Grafts must provide immediate load-bearing and structural support.
    • Long-term regeneration requires successful cell maturation, integration, and remodeling within the joint.

    Conclusions:

    • Tissue engineering holds promise for overcoming organ failure and restoring joint function.
    • Addressing the challenges of immediate functionality and long-term regeneration is key to successful joint repair grafts.
    • Continued research in tissue engineering is vital for treating degenerative joint disease and improving patient quality of life.