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Published on: November 7, 2020

Survival after liver transplantation for hepatitis C is unchanged over two decades in Canada

K Ds Watt1, K W Burak, M Deschênes

  • 1Mayo Clinic, Rochester, Minnesota 55905, USA. watt.kymberly@mayo.edu

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
|February 27, 2008
PubMed

Insights

The

Area of Science:

  • Hepatology
  • Transplantation Medicine
  • Virology

Background:

  • Hepatitis C virus (HCV) recurrence post-transplant is a major cause of graft failure and mortality.
  • An 'era effect' suggesting worse outcomes in recent years for HCV liver transplant recipients has been hypothesized.

Purpose of the Study:

  • To investigate the presence of an 'era effect' on liver transplant outcomes in HCV patients in Canada.
  • To analyze survival rates based on the year of liver transplantation for HCV infection.

Main Methods:

  • Analysis of a Canadian transplantation registry database.
  • Inclusion of 1002 liver transplantation recipients with HCV infection.
  • Evaluation of survival rates across different transplantation eras.

Main Results:

  • No significant 'era effect' was observed in Canadian HCV liver transplant recipients.
  • Two-year survival rates ranged from 76% to 83% across all groups.
  • Five-year survival rates ranged from 69% to 72% across all groups.

Conclusions:

  • Liver transplantation remains a beneficial treatment for patients with HCV infection in Canada.
  • Outcomes for HCV liver transplant recipients have not worsened in recent years.
  • Consistent survival benefits are demonstrated for HCV patients undergoing liver transplantation.

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