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Related Experiment Video

Updated: Jul 7, 2026

Conjunctival Commensal Isolation and Identification in Mice

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

The role of complement in ocular pathology.

Nalini S Bora¹, Purushottam Jha, Puran S Bora

¹Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, 4301 West Markham, Mail slot 523, Little Rock, AR 72205, USA. nbora@uams.edu

Seminars in Immunopathology

|February 27, 2008

Summary

The eye

Area of Science:

Ocular immunology and complement biology.

Background:

The complement system and its regulatory proteins are present in the healthy human and rodent eye.
Complement activation and regulation are implicated in ocular diseases like keratitis, uveitis, and age-related macular degeneration (AMD).
Genetic variations in complement components are linked to AMD.

Purpose of the Study:

To explore the role of the complement system in ocular health and disease.
To review the therapeutic potential of complement regulatory proteins for ocular conditions.

Main Methods:

Review of existing literature on complement system function in the eye.
Analysis of studies investigating complement regulatory proteins in animal models of ocular disease.

Main Results:

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The complement system is active in the eye and its dysregulation contributes to ocular pathologies.
Animal models show promise for treating ocular diseases using recombinant complement regulatory proteins.

Conclusions:

Complement system dysregulation is a key factor in several serious eye diseases.
Recombinant complement regulatory proteins represent a potential future therapeutic strategy for treating keratitis, uveitis, and AMD.