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A defective angiogenesis in chronic kidney disease

Narisa Futrakul1, Punnee Butthep, Narumon Laohareungpanya

  • 1King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Renal Failure
|February 27, 2008
PubMed

Insights

Chronic kidney disease (CKD) patients show reduced blood flow, increased vascular injury markers like circulating endothelial cells (CEC), and deficient vascular endothelial growth factor (VEGF). This suggests impaired blood vessel repair in advanced CKD.

Area of Science:

  • Nephrology
  • Vascular Biology
  • Cardiovascular Research

Background:

  • Chronic kidney disease (CKD) is associated with progressive reduction in peritubular capillary blood flow.
  • Altered vascular homeostasis is suspected in CKD, necessitating verification of underlying mechanisms.

Purpose of the Study:

  • To investigate vascular injury in CKD patients.
  • To examine the balance between vascular endothelial growth factor (VEGF) and endostatin.

Main Methods:

  • Assessment of circulating endothelial cells (CEC) as a marker of vascular injury.
  • Quantification of VEGF and endostatin levels.

Main Results:

  • CKD patients exhibited deficient VEGF levels.
  • Elevated levels of endostatin and CEC were observed in CKD patients.

Conclusions:

  • Increased CEC indicates heightened vascular injury activity.
  • Deficient VEGF alongside elevated endostatin suggests impaired angiogenesis in CKD.
  • This imbalance may explain the progression of renal microvascular disease in advanced CKD.
Abstract

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