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Hyperleukocytosis from arsenic trioxide

Michael Levy1, Marcia M Wofford, Bayard L Powell

  • 1Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Pediatric Blood & Cancer
|February 27, 2008
PubMed

We report the case of a 14-year-old male treated with arsenic trioxide for recurrent acute promyelocytic leukemia. He developed hyperleukocytosis (WBC 111.6 x 10(9)/L) which then resolved while continuing daily arsenic. Hyperleukocytosis without other complications may not be an indication for adding cytotoxic therapy or steroids, nor for discontinuing arsenic trioxide therapy in children.

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