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Updated: Jul 7, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique
Marco Tovar1, Mark J Siedner, Robert H Gilman
1Departamento de Microbiologia, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru.
Abstract:
Tests for pleural tuberculosis are insensitive and expensive. We compared nonproprietary microscopic-observation drug-susceptibility (MODS) culture with Löwenstein-Jensen culture for evaluation of pleural specimens. MODS culture was associated with greatly increased diagnostic sensitivity and shorter time to diagnosis, compared with Löwenstein-Jensen culture (sensitivity of culture of biopsy specimens, 81% vs.51%; time to diagnosis, 11 days vs. 24 days; P < .001). The MODS technique is inexpensive, allows drug-susceptibility testing, and is a considerably improved diagnostic method for pleural tuberculosis.
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