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Updated: Jul 7, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Brain stimulation & the treatment of refractory psychiatric disorders
Charles F Zorumski1, Gabriel de Erausquin, Mehmet Dokucu
1Department of Psychiatry, Washington University School of Medicine, USA. zorumskc@wustl.edu
Abstract:
Many patients with psychiatric disorders are refractory to current treatments, prompting a search for novel therapies. Based on the efficacy of electroconvulsive therapy, there is interest in developing other brain stimulation methods in psychiatry. Alternatives include vagal nerve stimulation, repetitive transcranial magnetic stimulation and deep brain stimulation. This paper reviews these methods, highlighting strategies currently being used and developed at Washington University and Barnes-Jewish Hospital in St. Louis.
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