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Impaired left ventricular synchronicity in hypertensive patients with ventricular hypertrophy

Hong-wei Tan1, Guo-ling Zheng, Li Li

  • 1Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, China.

Journal of Hypertension
|February 28, 2008
PubMed

Insights

Left ventricular hypertrophy (LVH) impairs systolic synchronicity in hypertensive patients. Tissue Doppler imaging (TDI) effectively detects these myocardial abnormalities, aiding in diagnosis.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Hypertension Research

Background:

  • Left ventricular hypertrophy (LVH) is a common adaptation to hypertension.
  • The impact of LVH on left ventricular synchronicity and dyssynchrony prevalence in hypertensive patients remains unclear.

Purpose of the Study:

  • To investigate the influence of LVH on left ventricular synchronicity.
  • To determine the prevalence of left ventricular dyssynchrony in hypertensive patients with LVH.

Main Methods:

  • Tissue Doppler imaging (TDI) was utilized in 115 hypertensive patients and 30 controls.
  • Hypertensive patients were stratified into LVH and non-LVH groups based on left ventricular mass index (LVMI).
  • Systolic and diastolic asynchrony were quantified using time to peak myocardial systolic contraction (Ts-max) and early diastolic relaxation (Te-max) measurements.

Main Results:

  • Systolic asynchrony (Ts-max) was significantly increased in both non-LVH and LVH hypertensive groups compared to controls, and further elevated in the LVH group.
  • Diastolic asynchrony (Te-max) was prolonged in hypertensive patients, most notably in the LVH group.
  • LVH patients exhibited a higher prevalence of both systolic and diastolic asynchrony; a Ts-max > 88 ms demonstrated 68% sensitivity and 71% specificity for detecting LVH.

Conclusions:

  • Left ventricular systolic synchronicity is demonstrably impaired in hypertensive patients with LVH.
  • TDI proves valuable for detecting myocardial abnormalities associated with LVH in hypertensive individuals.
Abstract

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