Related Experiment Video
Updated: Jul 7, 2026
04:53
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Fish oil in critical illness.
Konstantin Mayer1, Werner Seeger
1Department of Internal Medicine, Pulmonary and Critical Care Medicine, Justus Liebig University Giessen, Germany. konstantin.mayer@innere.med.uni-giessen.de
Current Opinion in Clinical Nutrition and Metabolic Care
|February 28, 2008
Summary
Fish oil
Area of Science:
- Clinical Nutrition
- Immunonutrition
- Critical Care Medicine
Background:
- Omega-3 (n-3) fatty acids from fish oil modulate lipid mediators and cellular functions.
- They compete with arachidonic acid (n-6) and are precursors to anti-inflammatory resolvins.
Purpose of the Study:
- To review recent advances in the clinical application of n-3 lipids from fish oil in intensive care settings.
- To evaluate their impact on immune response and clinical outcomes.
Main Methods:
- Review of existing literature on fish oil supplementation in clinical nutrition.
- Analysis of studies involving enteral and parenteral nutrition with n-3 fatty acids.
Main Results:
- Enteral n-3 fatty acids improved ventilation in acute lung injury and reduced mortality in some septic patients.
- Parenteral n-3 fatty acids enhanced immunologic parameters and reduced hospital stay in surgical patients.
- High-dose fish oil infusions induced rapid immunologic changes.
Conclusions:
- Fish oil inclusion in nutrition can positively influence immune responses and outcomes by counteracting n-6 fatty acid effects.
- Beneficial effects observed in surgical and acute respiratory distress syndrome patients.
- Data on enteral use in septic patients remain controversial; further randomized trials are needed.
Related Concept Videos
01:29Chronic Pancreatitis II: Collaborative Care
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
01:22Heart Failure VI: Adjunct Therapies
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
01:30Acute Pancreatitis II: Clinical Manifestations and Management
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
01:27Acute Pancreatitis I: Introduction
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:25Acute Pancreatitis I: Introduction
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...