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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...

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Updated: Jul 7, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Published on: June 10, 2025

Whipple disease.

Thomas Marth1, Thomas Schneider

  • 1St Josef Hospital, Zell/Mosel, Germany bMedical department I, Charité - University Medicine Berlin, CBF, Berlin, Germany. t.marth@krankenhaus-zell.de

Current Opinion in Gastroenterology
|February 28, 2008
PubMed
Summary
This summary is machine-generated.

Advances in molecular technology and immunology have improved Whipple disease diagnosis and therapy. Research is enhancing our understanding of this rare infection, leading to better patient outcomes.

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Area of Science:

  • Molecular biology
  • Immunology
  • Infectious diseases

Background:

  • Whipple disease is a rare infection with complex etiology and pathogenesis.
  • Molecular technology and immunology have significantly advanced the understanding of this disease.

Purpose of the Study:

  • To review recent findings in Whipple disease.
  • To contextualize novel discoveries in clinical medicine and therapy.

Main Methods:

  • 16S rRNA sequencing for bacterial phylogeny.
  • Bacterial culture and genome analysis.
  • Development of PCR and immunohistochemistry for diagnosis.

Main Results:

  • Phylogeny of the causative bacterium determined.
  • Improved diagnostic and monitoring tools developed (PCR, immunohistochemistry).
  • Evidence suggests defects in T-cell and macrophage immunity.
  • First prospective antibiotic therapy study data forthcoming.

Conclusions:

  • Molecular genetics and immunology findings rapidly translated to clinical practice.
  • European Consortium on Whipple Disease facilitated research and data sharing.
  • Improved diagnostic and therapeutic strategies achieved for Whipple disease patients.