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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
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Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

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Related Experiment Video

Updated: Jul 7, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Normal-tension glaucoma: is it different from primary open-angle glaucoma?

M Bruce Shields1

  • 1Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA. bruce.shields@yale.edu

Current Opinion in Ophthalmology
|February 28, 2008
PubMed
Summary
This summary is machine-generated.

Normal-tension glaucoma (NTG) shares similarities with primary open-angle glaucoma (POAG), but NTG involves more non-pressure-related factors. Managing NTG requires controlling intraocular pressure (IOP) while considering other risk factors for optic nerve health.

Related Experiment Videos

Last Updated: Jul 7, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Normal-tension glaucoma (NTG) is a prevalent form of open-angle glaucoma with unclear pathogenic mechanisms.
  • Understanding the interplay between intraocular pressure (IOP) and IOP-independent factors in NTG is crucial.

Purpose of the Study:

  • To review recent literature on the mechanisms of glaucomatous damage in NTG.
  • To explore current and future treatment strategies for patients with NTG.

Main Methods:

  • Literature review of recent studies on normal-tension glaucoma.
  • Analysis of research on glaucomatous optic neuropathy mechanisms and treatment.

Main Results:

  • NTG and primary open-angle glaucoma (POAG) are viewed as a continuum, with IOP being a primary factor in POAG and additional factors significant in NTG.
  • Subsets of NTG patients show varying importance of IOP, blood flow, and other risk factors.

Conclusions:

  • IOP control is fundamental in managing NTG, but other factors affecting optic nerve head perfusion must be considered.
  • Future treatment may involve neuroprotective agents and a deeper understanding of IOP-independent mechanisms.