Related Experiment Video

Updated: Jul 7, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Pleural mesothelioma: diagnostic problems and evaluation of prognostic factors

Hoda M Ismail1, Mohamed A Akram A Nouh, Iman L Abulkheir

  • 1The Department of Pathology, National Cancer Institute, Cairo University. hodanci@hotmail.com

Journal of the Egyptian National Cancer Institute
|February 28, 2008
PubMed
Abstract

Insights

Malignant pleural mesothelioma (MPM) in Egypt, linked to asbestos, shows a high incidence. The study highlights p27 as a potential prognostic marker for this increasing health concern.

Area of Science:

  • Oncology
  • Pathology
  • Environmental Health

Background:

  • Malignant pleural mesothelioma (MPM) in Egypt is primarily linked to environmental asbestos exposure.
  • The disease disproportionately affects women and young adults.
  • Immunohistochemistry and ultrastructural analysis are crucial for diagnosis, with p27Kip1 identified as a key cell cycle regulator and potential tumor suppressor.

Purpose of the Study:

  • To conduct a comprehensive clinicopathologic, immunohistochemical, and ultrastructural examination of mesothelioma in Egyptian patients.
  • To identify significant prognostic factors influencing mesothelioma outcomes in the region.

Main Methods:

  • A cohort of 61 MPM cases was analyzed.
  • Immunohistochemical staining was performed using monoclonal antibodies for CK5/6, calretinin, vimentin, CD15, CEA, and p27.

Main Results:

  • Over half of the patients resided in asbestos-endemic areas, with 50.8% presenting with the epithelioid type.
  • Immunohistochemical markers showed high positivity rates: CK5/6 (73.8%), vimentin (63.9%), and calretinin (80.3%).
  • A significant correlation was found between p27 expression and histopathologic type, and between overall survival and age, histopathologic type, and disease stage.

Conclusions:

  • MPM represents a significant and underestimated public health issue in Egypt.
  • A panel of immunohistochemical markers is essential for accurate mesothelioma evaluation.
  • p27 demonstrates potential as a biologic prognostic marker for mesothelioma, warranting further investigation in larger cohorts.

More Related Videos

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Related Concept Videos

Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Pneumothorax-II01:27

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Endoscopic Studies I: Bronchoscopy and Thoracoscopy01:30

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due to...
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...