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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Hedgehog signalling in vascular development.

Takashi Nagase1, Miki Nagase, Masafumi Machida

  • 1Clinical Research Centre, National Hospital Organisation Murayama Medical Centre, Musashimurayam-shi, Tokyo, 208-0011, Japan.

Angiogenesis
|February 28, 2008
PubMed
Summary
This summary is machine-generated.

Hedgehog signaling proteins are crucial for embryonic and adult development, influencing blood vessel formation (angiogenesis). This review highlights their essential role in both embryonic and postnatal vascular development.

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A Method for Labeling Vasculature in Embryonic Mice
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A Method for Labeling Vasculature in Embryonic Mice

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cancer Biology

Background:

  • Hedgehog proteins are key morphogens in embryonic development, adult tissue maintenance, and cancer.
  • Aberrant Hedgehog signaling is linked to various cancers, including basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma.
  • Recent research implicates Hedgehog signaling in angiogenesis.

Purpose of the Study:

  • To review the multifaceted roles of Hedgehog signaling in embryonic and postnatal vascular development.
  • To emphasize the critical temporal window of Hedgehog-dependent angiogenesis during development.

Main Methods:

  • Literature review of Hedgehog signaling in vascular development.
  • Illustration using a whole mouse embryo culture system to demonstrate temporal importance.

Main Results:

  • Hedgehog signaling plays a significant role in both embryonic and adult angiogenesis.
  • Specific developmental contexts highlight the importance of Hedgehog signaling in embryonic angiogenesis.
  • A critical temporal window for Hedgehog-dependent angiogenesis exists during development.

Conclusions:

  • Hedgehog signaling is integral to both embryonic and postnatal vascular development.
  • Understanding this signaling pathway is crucial for developmental biology and cancer research.
  • The temporal dynamics of Hedgehog-dependent angiogenesis warrant further investigation.