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Updated: Jul 7, 2026
07:50
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
Interventional approaches to acute venous thromboembolism
1Interventional Radiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA. vedanthams@mir.wustl.edu
Seminars in Respiratory and Critical Care Medicine
|February 28, 2008
Summary
Minimally invasive endovascular therapies offer new aggressive treatments for venous thromboembolism (VTE). Pharmacomechanical thrombolysis shows promise for pulmonary emboli (PE) and deep venous thrombosis (DVT) in select patients.
Area of Science:
- Vascular Medicine
- Interventional Cardiology
- Endovascular Surgery
Background:
- Minimally invasive technologies have advanced venous thromboembolism (VTE) treatment.
- Percutaneous techniques are increasingly used for aggressive VTE management.
Purpose of the Study:
- To outline risks and benefits of endovascular VTE therapies.
- To identify clinical scenarios favoring endovascular treatment.
- To update on new modalities for VTE.
Main Methods:
- Review of endovascular VTE therapies.
- Discussion of pharmacomechanical thrombolysis.
- Analysis of patient selection for catheter-based interventions.
Main Results:
- Pharmacomechanical thrombolysis is a promising VTE treatment.
- Catheter-based interventions are suitable for compromised PE patients unresponsive to systemic therapy.
- Pharmacomechanical thrombolysis is indicated for phlegmasia cerulea dolens, IVC occlusion, and iliofemoral DVT.
Conclusions:
- Individualized patient selection is crucial for endovascular VTE treatment.
- Further randomized trials are needed to validate endovascular techniques.
- Multidisciplinary collaboration is essential for advancing VTE interventions.
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